The Yellow Submarine finished fifth last season, but an indifferent start to the new campaign has seen Escriba lose his job.
Villarreal 20/1 to win EL
Coincidentally, he suffered the same fate at Getafe in April 2016 after a defeat to Villarreal.
Fellow coaches Josep Alcacer and Jose Mascaros have also departed the club.
Villarreal delayed training on Monday ahead of the expected announcement of Escriba’s replacement later in the day.